fomepizole as a first-line treatment of patients with methanol poisoning
نویسندگان
چکیده
methanol is responsible for a life-threatening poisoning. fomepizole, a potent alcohol dehydrogenase inhibitor, is an efficient and safe antidote that prevents or reduces toxic methanol metabolism. although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. treatment should be started as soon as possible, based on history and initial findings including anion gap metabolic acidosis, while awaiting measurement of serum alcohol concentration. administration is easy (15 mg/ kg-loading dose, either intravenously or orally, regardless of alcohol concentration, followed by intermittent 10 mg/kg-doses every 12 hours until alcohol concentration becomes less than 30 mg/dl). there is no need to monitor fomepizole concentration. if administered early, fomepizole prevents methanol-related visual and neurological injuries. when administered prior to the onset of significant acidosis or organ injury, fomepizole may obviate the need for hemodialysis. when dialysis is indicated, 1 mg/kg/h-continuous infusion should be provided to compensate for its elimination. its side-effects are rarely serious and with a lower occurrence than ethanol. fomepizole is contraindicated in case of allergy to pyrazoles. it is both efficacious and safe in the pediatric population, but is not recommended during pregnancy. in conclusion, fomepizole is an effective and safe first-line antidote for methanol poisoning.
منابع مشابه
Fomepizole as a First-line Treatment of Patients with Methanol Poisoning
Methanol is responsible for a life-threatening poisoning. Fomepizole, a potent alcohol dehydrogenase inhibitor, is an efficient and safe antidote that prevents or reduces toxic methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, based on history and initial findings in...
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چکیده ندارد.
15 صفحه اولNeurologic Complications of Methanol Poisoning: A Clinicoepidemiological Report from Poisoning Treatment Centers in Tehran, Iran
Background: In this study we sought to investigate clinical findings (with a focus on neurologic effects) and also to analyze outcomes of a series of patients with methanol poisoning admitted to two poisoning treatment centers in Tehran, Iran. Methods: In this prospective cross-sectional study, methanol-poisoned patients admitted to departments of forensic medicine and toxicology of Loghman Hak...
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عنوان ژورنال:
asia pacific journal of medical toxicologyجلد ۳، شماره Supplement ۱، صفحات ۳-۳
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